The Indian ace was beaten in straight sets by Japan's Akiko Morigami.
Madison Keys swept past Wimbledon champion Elena Rybakina 6-2, 6-4 at the Cincinnati Open on Friday, setting up a semi-final clash with Petra Kvitova after the Czech defeated Ajla Tomljanovic.
Novak Djokovic, who claimed his fourth US Open and last major title in 2023, said he has "earned the right" to pick his schedule.'
Carlos Alcaraz said he will be "at 100%" for the US Open despite stopping his training in New York on Saturday as a precaution after twisting his ankle.
Earlier, title holder Borna Coric beat American Sebastian Korda 7-6 (5), 6-4, while another home hope Taylor Fritz survived a first-set thriller to beat Czech Jiri Lehecka 7-6 (14), 6-2.
The bull-like Alcaraz, playing only his second Grand Slam final compared to Djokovic's record 35, put on a show
Britain's Cameron Norrie stunned world number one Carlos Alcaraz to reach the third round of the Paris Masters.
Defending champion Serena Williams finished her last US Open tune-up in style by beating Romanian third seed Simona Halep 6-3, 7-6(5) to win the Western & Southern Open on Sunday.
Serena Williams' scored a ruthless 6-3, 6-1 win over Bethanie Mattek to advance to the quarter-finals of the Cincinnati Open
They were beaten by the top-seeded pair of Maria Elena Camerin and Gisela Dulko.
The five top contenders for the men's title at the US Open.
Aryna Sabalenka returns to the US Open as the reigning champion and bookmakers' favourite, but her 2025 season has been anything but smooth sailing.
Russia's Maria Sharapova will face Serbia's Jelena Jankovic in the Cincinnati Open final after the pair enjoyed solid victories in their semi-finals on Saturday. Sharapova recovered from a poor start to beat fellow-Russian and world number two Vera Zvonareva 2-6, 6-3, 6-3 to reach her fourth final of the season while Jankovic beat Germany's Andrea Petkovic 7-6, 6-1.
World number two Rafa Nadal scraped into the quarter-finals of the Cincinnati Open after beating fellow Spaniard Fernando Verdasco 7-6, 6-7, 7-6 in a fierce battle on Thursday but his rivals all had comfortable paths into the last eight.
The world number closed out the victory despite a few service wobbles late on, improving her win-loss record against Rybakina to 8-5.
Top-seed Jelena Jankovic and second seed Caroline Wozniacki suffered surprise third-round exits in the Cincinnati Open on Thursday.
The Cincinnati Open claimed two more high-profile victims on Thursday with Grand Slam champions Li Na and Petra Kvitova crashing out, while Russian pair Maria Sharapova and Vera Zvonareva crunched their opponents en route to the quarter-finals.
Sania Mirza, seeded ninth, advanced with a 6-1, 0-6, 6-1 victory over Finland's Emma Laine.
World number one Dinara Safina will take on a rejuvenated Jelena Jankovic in the final of the Cincinnati Open after hugely contrasting wins on Saturday. Russian Safina stormed into her eighth final of the year with a 6-2, 6-0 demolition of Italian Flavia Pennetta, while fifth seed Jankovic saved four match points to beat fourth seed Elena Dementieva 7-6, 0-6, 7-6 after two hours and 46 minutes.
Serena Williams, coming off a double Olympic gold medal-winning performance in London, said she was feeling the pace of a hectic schedule after a lethargic display in her 6-3, 6-0 win over Urszula Radwanska on Thursday.
Russia's Maria Sharapova beat Serbia's Jelena Jankovic 4-6, 7-6, 6-3 to win the Cincinnati Open on Sunday and install herself as one of the favourites for the US Open.
Britain's Andy Murray won the Cincinnati Open on Sunday when his opponent in the final, Serbia's world number one Novak Djokovic, retired injured.
Five top contenders for the women's title at the US Open.
Olympic champion Andy Murray suffered a second pre-US Open setback in as many weeks when he was knocked out of the Cincinnati Open in the third round on Thursday, losing 6-4, 6-4 to France's Jeremy Chardy.
World number one Dinara Safina scrambled past Italian Roberta Vinci 2-6, 7-5, 6-4 to reach the third round of the Cincinnati Open on Tuesday. World number 46 Vinci served for the match at 5-4 in the second set but her nerve failed her at the crucial time.
Making her first semi-final appearance after quarter-final exits at each of the last two editions of the tournament, Sania confessed that she ran out of steam towards the end.
Rafael Nadal and Roger Federer, numbers two and three in the world, suffered surprise defeats to Mardy Fish and Tomas Berdych respectively in an entertaining quarter-finals day at the Cincinnati Open on Friday.
Kim Clijsters survived three match points before a rain break then produced a remarkable comeback after the weather cleared to beat Maria Sharapova 2-6, 7-6, 6-2 and win the Cincinnati Open on Sunday.
Ana Ivanovic will meet Kim Clijsters in the Cincinnati Open semi-finals after progressing along with Russian teenager Anastasia Pavlyuchenkova and Maria Sharapova on Friday.
Carlos Alcaraz has vowed to learn from the incident and ensure it doesn't happen again
Sinner won in Cincinnati this week to claim his fifth title of a breakout season before the revelation that he avoided a ban over two positive tests
Novak Djokovic is returning to the US for the first time in two years after being denied entry due to being unvaccinated for COVID-19.
Russia's Elena Dementieva lost 6-1, 6-3 to compatriot Anastasia Pavlyuchenkova in the second round of the rain-hit Cincinnati Open on Wednesday, but Maria Sharapova and Kim Clijsters both advanced to the third round.
A rejuvenated Jelena Jankovic upset world number one Dinara Safina 6-4, 6-2 to win the Cincinnati Open on Sunday. The fifth-seeded Serb took advantage of an error-strewn display from the Russian to clinch her second title of the year.
A big puff of pizzazz seeped out of the Cincinnati Open on Thursday as its top seed Caroline Wozniacki slipped out and star attraction Serena Williams quit the tournament, along with third seed Victoria Azarenka.
China's Li Na defeated a battling Venus Williams 7-5, 3-6, 6-1 to reach the final of the Cincinnati Open on Saturday after an enthralling two-hour nine minutes encounter.
Maria Sharapova will meet Kim Clijsters in the final of the Cincinnati Open on Sunday after the pair came through contrasting semi-final ties.
Mirza beat Lepchenko 6-2, 6-2 to reach the quarter-finals in Cincinnati for the third straight year.
China's Li Na showed plenty of character as she fought back to beat German Angelique Kerber 1-6, 6-3, 6-1 and win the Cincinnati Open title on Sunday.